منابع مشابه
Intranasal administration of drugs.
OBJECTIVE To investigate how nasally applied substances distribute in the nose depending on the form of application. DESIGN Observer-blinded study. SETTING University hospital research unit. PARTICIPANTS Fifteen healthy volunteers aged 22 to 32 years. INTERVENTIONS Forms of application included (1) nasal drops applied with a pipette, (2) nasal spray, and (3) a system producing squirts. ...
متن کاملIntranasal administration of naloxone by paramedics.
INTRODUCTION Naloxone is a medication that is frequently administered in the field by paramedics for suspected opioid overdoses. Most prehospital protocols, however, require this medication to be given to patients intravenously (i.v.) or intramuscularly (i.m.). Unfortunately, intravenous line placement may be problematic and time-consuming in chronic i.v. drug users. There may also be a delay i...
متن کاملIntranasal administration of gentamicin in human subjects.
The effectiveness of gentamicin administered by the intranasal route in healthy human volunteers was studied. Thirty minutes after gentamicin in a solution of 1% sodium glycocholate was administered at 2 mg/kg of body weight, gentamicin concentrations of 2.48 +/- 0.42 mg/ml were present in the sera. Serum concentrations decreased to 0.94 +/- 0.13 mg/ml at 180 min. No serious side effects were o...
متن کاملcomparison of intranasal administration of diazepam,
safe and effective sedation methods are as much important for small pet birds as for the other animals not only for surgical procedures but also for safe handling and diagnostic and clinical procedures such as radiography, wound dressing, blood collection, endoscopy and fracture repair procedures. the aim of this study is comparison of sedation efficacy in intranasal administration of xylazine,...
متن کاملCutaneous drug delivery of capsaicin after in vitro administration of the 8% capsaicin dermal patch system.
OBJECTIVE Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Aδ fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. To date, no information is available regarding the cutaneous drug delivery of capsaicin following patch application....
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ژورنال
عنوان ژورنال: Cephalalgia
سال: 1993
ISSN: 0333-1024,1468-2982
DOI: 10.1046/j.1468-2982.1993.1302072-3.x